When selecting over-the-counter (OTC) painkillers, one has more choices than one would think. Two quite often used are Excedrin and ibuprofen. These drugs serve to control headaches, particularly tension and migraine headaches, by lowering inflammation in addition to momentarily relieving pain. These drugs, however, include NSAID components—aspirin and ibuprofen—so using them together raises your chance of negative effects.
Before using both, or spacing them out to prevent using too much of the same sort of pain medication, speak with your doctor. Generally speaking, you should properly space out any ibuprofen and Excedrin you need to take. Primary care physician Libbat-Tzion Shaham, MD of Medical Offices of Manhattan, provides detailed notes on the usage of these two over-the-counter drugs. Read the article.