Metformin is one of the most commonly prescribed medications for Type 2 diabetes, but new research suggests it may reduce some of the cardiovascular and fitness benefits typically gained through exercise. In a review of nine clinical trials involving more than 800 participants, individuals taking metformin alongside structured exercise programs experienced smaller improvements in aerobic fitness and blood pressure compared to those who exercised without the medication, raising important questions about how these therapies work together.
According to Dr. Victoria Finn, the findings reveal a “dissociation” between metformin’s intended purpose and its effect on exercise adaptation. While she emphasized that exercise remains a cornerstone of diabetes prevention and management, Dr. Finn noted that “metformin and physical exercise are not a universal combination for every patient.” She encourages patients to prioritize lifestyle interventions—including exercise, nutrition, weight management, and sleep optimization—and work with their healthcare provider to determine whether medication should be added based on individual risk factors and goals. Read the full article here.
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